ea0042p36 | (1) | Androgens2016
Hu Dong Gui
, Selth Luke
, Tarulli Gerard
, Meech Robyn
, Wijayakumara Dhilushi
, Chanawong Apichaya
, Russell Roslin
, Caldas Carlos
, Robinson Jessica LL
, Carroll Jason
, Tilley Wayne
, Mackenzie Peter
, Hickey Theresa
Glucuronidation is an enzymatic process that terminally inactivates steroid hormones, including estrogens and androgens, thereby influencing carcinogenesis in hormone-dependent cancers. While estrogens drive breast carcinogenesis via the estrogen receptor alpha (ERĪ±), androgens play a critical role as prohormones for estrogen biosynthesis and ligands for the androgen receptor (AR). Herein, the expression and regulation of two androgen inactivating UDP-glucuronosyltransfer...